Peroxisome-based metabolic engineering for biomanufacturing and agriculture

被引：5

作者：

Song, Shuyan ^{[1
,2
]}

Ye, Cuifang ^{[1
,2
]}

Jin, Yijun ^{[1
,2
]}

Dai, Huaxin ^{[3
]}

Hu, Jianping ^{[4
,5
]}

Lian, Jiazhang ^{[1
,2
]}

Pan, Ronghui ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Chem & Biol Engn, Coll Agr & Biotechnol, State Key Lab Rice Biol & Breeding, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Zhejiang, Peoples R China

[3] Beijing Life Sci Acad, Beijing 102209, Peoples R China

[4] Michigan State Univ, Dept Energy, Plant Res Lab, E Lansing, MI 48824 USA

[5] Michigan State Univ, Plant Biol Dept, E Lansing, MI 48824 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2024年 / 42卷 / 09期

基金：

中国国家自然科学基金;

关键词：

HARNESSING YEAST PEROXISOMES; POLYHYDROXYALKANOATE; BIOSYNTHESIS; PATHWAY; ORGANELLES;

D O I：

10.1016/j.tibtech.2024.02.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological manufacturing and agriculture. In this review, we summarize the remarkable achievements in peroxisome engineering in yeast, the industrially popular biomanufacturing chassis host, to produce various biocompounds. We also review progress in plant peroxisome engineering, a field that has already exhibited high potential in both biomanufacturing and agriculture. Moreover, we outline various experimentally validated strategies to improve the efficiency of engineered pathways in peroxisomes, as well as prospects of peroxisome engineering.

引用

页码：1161 / 1176

页数：16

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