Carbapenem resistant Campylobacter jejuni bacteremia in a Bruton's X-linked agammaglobulinemia patient

被引：0
|
作者：
Zhuo, Ran [1 ]
Younes, Ramee L. [2 ]
Ward, Kevin [1 ]
Yang, Shangxin [1 ]
机构：
[1] Univ Calif Los Angeles, UCLA David Geffen Sch Med, Dept Pathol & Lab Med, 11633 San Vicente Blvd, Los Angeles, CA 90049 USA
[2] Univ Calif Los Angeles, UCLA David Geffen Sch Med, Div Infect Dis, Los Angeles, CA USA
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2024年 / 43卷 / 12期
关键词：
Carbapenem resistance; Campylobacter jejuni; OXA-61; Gene duplication; Porin mutation; Recurrent bloodstream infections; EFFLUX PUMP; EXPRESSION; MECHANISM; REPRESSOR; STRAINS; CMEABC;
D O I：
10.1007/s10096-024-04937-1
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Immunocompromised patients are prone to recurrent Campylobacter infections. We report a case of recurrent multi-drug resistant Campylobactor jejuni bloodstream infections in a Bruton's X-linked agammaglobulinemia patient with prolonged ertapenem treatment. The isolate from the fifth recurrence developed carbapenem resistance, which is associated with mutations in a porin gene porA, and promoter changes and duplication of chromosomal blaOXA-61 gene. Combination therapy using cefepime and doxycycline (later switched to moxifloxacin) cleared the infection.
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收藏
页码：2459 / 2463
页数：5
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