2-Bromopyridines as Versatile Synthons for Heteroarylated 2-Pyridones via Ru(II)-Mediated Domino C-O/C-N/C-C Bond Formation Reactions

被引：0

作者：

Drev, Miha ^{[1
]}

Brodnik, Helena ^{[1
]}

Groselj, Uros ^{[1
]}

Perdih, Franc ^{[1
]}

Svete, Jurij ^{[1
]}

Stefane, Bogdan ^{[1
]}

Pozgan, Franc ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, Vecna Pot 113, Ljubljana 1000, Slovenia

来源：

MOLECULES | 2024年 / 29卷 / 18期

关键词：

ruthenium catalysis; heterocycles; C-H activation; pyridones; 2-bromopyridines; DIRECT ALKYLATION; H ALKYLATION; ARYLATION; PYRIDONES; HETEROCYCLES; ACTIVATION; CHEMISTRY; DIENES;

D O I：

10.3390/molecules29184418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)-KOPiv-Na2CO3 catalytic system. Unsubstituted 2-bromopyridine was successfully converted to the penta-heteroarylated 2-pyridone product using this method. Preliminary mechanistic studies revealed a possible synthetic pathway leading to the multi-heteroarylated 2-pyridone products, involving consecutive oxygen incorporation, a Buchwald-Hartwig-type reaction, and C-H bond activation.

引用

页数：13

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