The Role of Fibroblasts in Skin Homeostasis and Repair

被引:10
|
作者
Boraldi, Federica [1 ]
Lofaro, Francesco Demetrio [1 ]
Bonacorsi, Susanna [1 ]
Mazzilli, Alessia [1 ]
Garcia-Fernandez, Maria [2 ]
Quaglino, Daniela [1 ]
机构
[1] Univ Modena & Reggio Emilia, Dept Life Sci, I-41125 Modena, Italy
[2] Univ Malaga, Inst Biomed Invest IBIMA, Dept Human Physiol, Malaga 29010, Spain
关键词
fibroblast; extracellular matrix; mechanobiology; aging; skin repair; disease; proteomics; HUMAN DERMAL FIBROBLASTS; CANCER-ASSOCIATED FIBROBLASTS; IN-VITRO; ELASTIC FIBERS; MESENCHYMAL TRANSITION; CULTURED FIBROBLASTS; MECHANICAL MEMORY; MASS-SPECTROMETRY; PROTEOME ANALYSIS; HYALURONIC-ACID;
D O I
10.3390/biomedicines12071586
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain the extracellular matrix, ensuring the structural role of soft connective tissues; (2) secrete cytokines and growth factors; (3) communicate with each other and with other cell types, acting as signalling source for stem cell niches; and (4) are involved in tissue remodelling, wound healing, fibrosis, and cancer. This review focuses on the developmental heterogeneity of dermal fibroblasts, on their ability to sense changes in biomechanical properties of the surrounding extracellular matrix, and on their role in aging, in skin repair, in pathologic conditions and in tumour development. Moreover, we describe the use of fibroblasts in different models (e.g., in vivo animal models and in vitro systems from 2D to 6D cultures) for tissue bioengineering and the informative potential of high-throughput assays for the study of fibroblasts under different disease contexts for personalized healthcare and regenerative medicine applications.
引用
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页数:28
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