Unveiling the Impact of BMP9 in Liver Diseases: Insights into Pathogenesis and Therapeutic Potential

被引：0
|
作者：
Chen, Han [1 ,2 ]
Li, Ying-Yi [3 ]
Nio, Kouki [3 ]
Tang, Hong [1 ,2 ]
机构：
[1] Sichuan Univ, Ctr Infect Dis, West China Hosp, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Inst Infect Dis, Lab Infect & Liver Dis, West China Hosp, Chengdu 610041, Peoples R China
[3] Kanazawa Univ Hosp, Dept Gastroenterol, Kanazawa, Ishikawa 9208641, Japan
来源：
BIOMOLECULES | 2024年 / 14卷 / 08期
关键词：
BMP9; BMP signaling; liver disease; liver fibrosis; liver cancer; MORPHOGENETIC PROTEIN 9; GROWTH-FACTOR-BETA; RECEPTOR-LIKE KINASE-1; TGF-BETA; HEPCIDIN EXPRESSION; OSTEOBLAST DIFFERENTIATION; MESENCHYMAL TRANSITION; MONOCLONAL-ANTIBODY; SOLUBLE ENDOGLIN; PHASE-I;
D O I：
10.3390/biom14081013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the transforming growth factor beta(TGF-beta) family. While initially recognized for their role in bone formation, BMPs have emerged as significant players in liver diseases. Among BMPs with various physiological activities, this comprehensive review aims to delve into the involvement of BMP9 specifically in liver diseases and provide insights into the complex BMP signaling pathway. Through an enhanced understanding of BMP9, we anticipate the discovery of new therapeutic options and potential strategies for managing liver diseases.
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页数：26
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