Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications

The development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by pH changes. These films are composed of MIL-101(Fe) particles and pectin polymers. MIL-101(Fe) was chosen for its high surface area, stability in aqueous environments, and biocompatibility, ensuring low toxicity to normal cells. MIL-101(Fe)-embedded-pectin hydrogels were synthesized and characterized using Fourier-transformed infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometry, particle size analysis, and goniometry. Rheological analysis assessed the hydrogels' viscoelastic behavior, and UV-spectrophotometry was utilized for drug loading and release studies. The hydrogels exhibited shear-thinning properties, enhancing shape adaptability and recovery, crucial for wound-dressing applications. Controlled drug release was achieved by maintaining the PC solution's pH between 8.2 and 9.8 during the drug-loading step. The hydrogel film's impact on wound healing was evaluated through an in vitro wound healing assay, and cytotoxicity was assessed using a WST-1 cell proliferation assay with human dermal fibroblast cells. Results demonstrated that pectin composites enhance cell viability and support fibroblast cell migration without adverse effects, indicating their potential for effective wound healing applications. This study highlights the potential of MIL-101(Fe)-embedded-pectin hydrogels in advancing wound care technology.Graphical Abstract MIL-101(Fe)-embedded pectin film as wound dressing