Immunomodulatory molecules in colorectal cancer liver metastasis

被引:3
|
作者
Kong, Wei-Shuai [1 ,2 ]
Li, Jia-Jun [1 ]
Deng, Yu-Qing [1 ,2 ]
Ju, Huai-Qiang [1 ,2 ]
Xu, Rui-Hua [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, Dept Med Oncol, Sun Yat Sen Univ Canc Ctr,State Key Lab Oncol Sout, Guangzhou 510060, Peoples R China
[2] Chinese Acad Med Sci, Res Unit Precis Diag & Treatment Gastrointestinal, Guangzhou 510060, Peoples R China
基金
中国国家自然科学基金;
关键词
Colorectal cancer liver metastasis; Immunomodulatory molecule; Membrane protein; Secreted protein; Tumor microenvironment; REGULATORY T-CELLS; MISMATCH REPAIR-DEFICIENT; COLON-CANCER; IMMUNE CHECKPOINT; KUPFFER CELLS; TUMOR-CELLS; OPEN-LABEL; IMMUNOTHERAPY; EXPRESSION; TARGETS;
D O I
10.1016/j.canlet.2024.217113
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colorectal cancer (CRC) ranks as the third most common cancer and the second leading cause of cancer-related deaths. According to clinical diagnosis and treatment, liver metastasis occurs in approximately 50 % of CRC patients, indicating a poor prognosis. The unique immune tolerance of the liver fosters an immunosuppressive tumor microenvironment (TME). In the context of tumors, numerous membrane and secreted proteins have been linked to tumor immune evasion as immunomodulatory molecules, but much remains unknown about how these proteins contribute to immune evasion in colorectal cancer liver metastasis (CRLM). This article reviews recently discovered membrane and secreted proteins with roles as both immunostimulatory and immunosuppressive molecules within the TME that influence immune evasion in CRC primary and metastatic lesions, particularly their mechanisms in promoting CRLM. This article also addresses screening strategies for identifying proteins involved in immune evasion in CRLM and provides insights into potential protein targets for treating CRLM.
引用
收藏
页数:11
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