5-Fluorouracil-Induced Leukoencephalopathy: Report of Two Cases and Review of Literature

被引：0

作者：

Supreeth, R. N. ^{[1
]}

Hingmire, Sachin ^{[1
]}

Joshi, Aniruddha ^{[2
]}

机构：

[1] Deenanath Mangeshkar Hosp, Dept Med Oncol, Pune, India

[2] Deenanath Mangeshkar Hosp, Radiol, Pune, India

来源：

INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY | 2024年 / 45卷 / 06期

关键词：

5-fluorouracil; leukoencephalopathy; GI malignancies; neurotoxicity; MULTIFOCAL LEUKOENCEPHALOPATHY; TEGAFUR; THERAPY; CANCER;

D O I：

10.1055/s-0044-1779488

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

5-fluorouracil (5FU) forms an important component of chemotherapy regimens used in various gastrointestinal (GI) adenocarcinomas and head and neck squamous cell carcinomas. Leukoencephalopathy is a rare adverse effect of 5FU, mediated by hyperammonemia and hyperlactatemia. We report cases of two patients with GI adenocarcinomas who developed neurological symptoms while on 5FU infusion. The neuroimaging and biochemical parameters were suggestive of toxic leukoencephalopathy. They were managed with cessation of the drug and short-term antiepileptic therapy. We also discuss the pathophysiology of this adverse effect and its management.

引用

页码：546 / 549

页数：4

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