[1] CNS Campus Neurol, Torres Vedras, Portugal
[2] Univ Lisbon, IMM Inst Med Mol Joao Lobo Antunes, Fac Med, Lisbon, Portugal
[3] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Braga, Portugal
[4] BIAL Portela & Ca SA, Coronado, Portugal
[5] Paracelsus Elena Klin, Kassel, Germany