Delayed Trastuzumab-induced Cardiotoxicity Leading to Severe Left Ventricular Dysfunction

被引：0

作者：

Misumi, Ikuo ^{[1
]}

Nishimura, Reiki ^{[2
]}

Nakamura, Shota ^{[3
]}

Sato, Koji ^{[4
]}

Dekita, Miwa ^{[4
]}

Usuku, Hiroki ^{[5
]}

Tsujita, Kenichi ^{[5
]}

机构：

[1] Ueki Hosp, Dept Cardiol, Kumamoto, Japan

[2] Kumamoto Brest & Gastrointestinal Surg Hosp, Dept Surg, Kumamoto, Japan, Japan

[3] Kumamoto Shinto Gen Hosp, Dept Cardiol, Kumamoto, Japan

[4] Kumamoto City Hosp, Dept Cardiol, Kumamoto, Japan

[5] Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto, Japan

来源：

INTERNAL MEDICINE | 2024年

关键词：

Delayed trastuzumab-induced cardiotoxicity; Septal injury; Cardiac magnetic resonance;

D O I：

10.2169/internalmedicine.4144-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An 81-year-old woman presented to our hospital with dyspnea. She had been treated with trastuzumab for nine years. Chest radiography revealed pleural effusion. Transthoracic echocardiography revealed dyskinesis of the interventricular septum (IVS). Cardiac magnetic resonance imaging revealed increased native T1 values at the interventricular septum and apex, indicating myocardial edema or fibrosis in these areas. A transthoracic echocardiogram after half a year revealed an increase in LVEF from 25% to 48%. Serial transthoracic echocardiography and cardiac magnetic resonance imaging were useful for evaluating the cardiac structure and function in the present case of delayed trastuzumab-induced myocardial injury.

引用

页数：9

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