Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection

被引：0

作者：

Xu, Shuaili ^{[1
,3
]}

Jia, Milan ^{[2
]}

Guo, Jiaqi ^{[3
]}

He, Jiachen ^{[3
]}

Chen, Xi ^{[2
,3
]}

Xu, Yi ^{[2
,3
]}

Hu, Wenbo ^{[2
,3
]}

Wu, Di ^{[3
]}

Wu, Chuanjie ^{[2
]}

Ji, Xunming ^{[1
,2
,3
,4
]}

机构：

[1] Capital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Lab Brain Disorders,Minist Sci & Technol, Beijing, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China

[3] Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing, Peoples R China

[4] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, 45 Changchun St, Beijing 100053, Peoples R China

来源：

STROKE | 2024年 / 55卷 / 09期

基金：

中国国家自然科学基金;

关键词：

circadian rhythm; incidence; ischemic stroke; neuroprotection; prognosis; ACUTE ISCHEMIC-STROKE; ELEVATION MYOCARDIAL-INFARCTION; REV-ERBS; CEREBRAL-ISCHEMIA; DIURNAL-VARIATION; GENE-EXPRESSION; CLOCK PROTEINS; MELATONIN; BLOOD; ACTIVATION;

D O I：

10.1161/STROKEAHA.124.046684

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed the effects of circadian variation on the incidence, pathophysiological processes, and prognosis of acute ischemic stroke. Furthermore, core clock genes, the cell-autonomous pacemakers of the circadian rhythm, affect the neurovascular unit-composing cells in a nonparallel manner after the same pathophysiological processes of ischemia/reperfusion. In this review, we discuss the influence of circadian rhythms and clock genes on each type of neurovascular unit cell in the pathophysiological processes of acute ischemic stroke.

引用

页码：2385 / 2396

页数：12

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