New Twists in the Chemistry of Thioureas: 1,3-Thiazolidines as a Vector of Sustainability

This study introduces a sustainable and pioneering cascade synthesis of 1,3-thiazolidine derivatives under eco-friendly conditions. The methodology transcends traditional approaches yielding complex novel compounds with unique N,S-heterocyclic structures. By operating at room temperature, utilizing green solvents, and minimizing excess of reactants, this procedure offers an innovative pathway for sustainable chemical development. Notably, this method not only prioritizes sustainability but also delivers high-purity products with exceptional yields. The simplicity of the process, requiring only a simple filtration and featuring short reaction times, underscores its efficiency and utility. A new sustainable method for synthesizing 1,3-N,S-heterocycles, including 1,3-thiazolidine-2-imines and 4,5-dihydrothiazol-2-amines is reported. This innovative approach offers considerable shorter reaction times with higher yields, reduced energy consumption, and the elimination of hazardous chemicals. Moreover, the process is scalable, as demonstrated by the reaction conducted on a 10 mmol scale. This method represents a significant advancement in producing pharmacologically relevant compounds. image