This study presents a comprehensive framework for understanding the key opportunities and barriers in implementing Industry 4.0 (I4.0) in Tunisian medium-sized enterprises (SMEs), using MICMAC (Matrice d'Impacts Crois & eacute;s, Multiplication Appliqu & eacute;e & agrave; un Classement) and DEMATEL (Decision-Making Trial and Evaluation Laboratory) methodologies, supported by a literature review and expert consultations. Both methods identify crucial opportunities such as digital collaboration and real-time information, along with barriers like under-utilization of academic knowledge and insufficient leadership commitment. While MICMAC emphasizes risk management, not fully recognized by DEMATEL, both converge on similar barriers with nuanced prioritization. Comparing these findings with existing literature highlights commonalities and differences in opportunities and barriers. The study underscores the importance of integrating sustainability and cost reduction into I4.0 frameworks and suggests incorporating technological readiness, leadership support, and innovative business models. For practical implementation, decision-makers should invest in advanced manufacturing technologies, foster collaboration with technology providers, and initiate pilot projects. Enhancing operational agility and efficiency through integrated digital platforms and adaptable systems is essential. Addressing barriers involves securing management support, improving technical expertise, managing resistance to change, and boosting research and development efforts.