Case Commentary: Extending our therapeutic range against multidrug-resistant Candida

被引：0

作者：

Adelman, Max W. ^{[1
,2
,3
,4
]}

Andes, David R. ^{[5
]}

机构：

[1] Houston Methodist Hosp, Dept Med, Div Infect Dis, Houston, TX 77030 USA

[2] Houston Methodist Res Inst, Ctr Infect Dis, Houston, TX 77030 USA

[3] Houston Methodist Hosp, Dept Med, Div Pulm Crit Care & Sleep, Houston, TX 77030 USA

[4] Weill Cornell Med, New York, NY 10065 USA

[5] Univ Wisconsin, Dept Med, Div Infect Dis, Madison, WI 53792 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2024年 / 68卷 / 08期

关键词：

Candida; antifungal agents; antifungal resistance; antifungal therapy; osteomyelitis; endocarditis; AZOLE RESISTANCE; SURVEILLANCE;

D O I：

10.1128/aac.00847-24

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Deep-seated Candida spp. infections may necessitate extended durations of antifungal therapy. Increasing resistance to first-line antifungals threatens the most common options for long-term treatment. In this issue, Ponta et al. (Antimicrob Agents Chemother 68:e00750-24, 2024, https://doi.org/10.1128/aac.00750-24) present cases in which they used rezafungin, a novel long-acting echinocandin antifungal, for extended durations. While excellent clinical evidence supports the short-term safety of rezafungin, these cases demonstrate that rezafungin may additionally have a role in long-term suppressive therapy for antifungal-resistant Candida spp. infections.

引用

页数：4

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