Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice

被引：0
|
作者：
Chen, Linfei [1 ]
Chen, Haowen [1 ]
Li, Yanting [1 ]
Kong, Jiaqi [1 ]
Ji, Xiaoya [1 ]
Tang, Jinglong [1 ]
机构：
[1] Qingdao Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Qingdao, Peoples R China
来源：
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2024年 / 211期
基金：
中国国家自然科学基金;
关键词：
AIR-FLOW; POLLUTION;
D O I：
10.3791/66818
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Olfactory impairment is a significant public health problem and independently predicts the risk of neurodegenerative diseases. Inhaled environmental pollutants exposure may impair olfaction; thereby, there is an urgent need for methods to evaluate the effects of inhaled environmental pollutants exposure on olfaction. Mice are ideal models for olfactory experiments because of their highly developed olfactory system and behavioral characteristics. To assess the effects of inhaled environmental pollutants exposure on olfactory function in mice, a detailed buried food test and social odor discrimination experiment is provided, including the experiment preparation, the selection and construction of experimental facilities, the testing process, and indexes of time. Meanwhile, timekeeping equipment, operational details, and the experimental environment are discussed to ensure the success of the assay. Zinc sulfate is used as the treatment to demonstrate the feasibility of the experimental approach. The protocol provides a simple and clear operational process for assessing the effects of inhaled environmental pollutants on olfactory function in mice.
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页数：10
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