Exploring the role of gut microbes in spondyloarthritis: Implications for pathogenesis and therapeutic strategies

被引:1
|
作者
Furst, Alec [1 ]
Gill, Tejpal [2 ]
机构
[1] Oregon Hlth & Sci Univ, Sch Med, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Div Arthrit & Rheumat Dis, Portland, OR 97239 USA
来源
关键词
Spondyloarthritis; Gut microbiome; Metabolome; Biomarker development; Therapeutic strategies; INFLAMMATORY-BOWEL-DISEASE; ARYL-HYDROCARBON RECEPTOR; ACUTE ANTERIOR UVEITIS; ANKYLOSING-SPONDYLITIS; TRYPTOPHAN-METABOLISM; PSORIATIC-ARTHRITIS; PLASMA METABONOMICS; FECAL MICROBIOTA; DYSBIOSIS; HLA-B27;
D O I
10.1016/j.berh.2024.101961
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The gut microbiota plays a pivotal role in regulating host immunity, and dysregulation of this interaction is implicated in autoimmune and inflammatory diseases, including spondyloarthritis (SpA). This review explores microbial dysbiosis and altered metabolic function observed in various forms of SpA, such as ankylosing spondylitis (AS), psoriatic arthritis (PsA), acute anterior uveitis (AAU), and SpA-associated gut inflammation. Studies on animal models and clinical samples highlight the association between gut microbial dysbiosis, metabolic perturbations and immune dysregulation in SpA pathogenesis. These studies have received impetus through nextgeneration sequencing methods, which have enabled the characterization of gut microbial composition and function, and host gene expression. Microbial/metabolomic studies have revealed potential biomarkers and therapeutic targets, such as short-chain fatty acids, and tryptophan metabolites, offering insights into disease mechanisms and treatment approaches. Further studies on microbial function and its modulation of the immune response have uncovered molecular mechanisms underlying various SpA. Understanding the complex interplay between microbial community structure and function holds promise for improved diagnosis and management of SpA and other autoimmune disorders.
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页数:11
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