Currently, although significant advancements have been made in understanding heat transfer coefficients and pressure decreases in different tube shapes, there is still a noticeable lack of detailed studies on the generation of entropy under flow boiling conditions. In this work, the entropy generation in micro-fin tubes (MFT1 and MFT2) and smooth tubes (ST1 and ST2) in flow boiling conditions experimentally investigated with refrigerant R513A. Research focused on evaluating influence of different input parameters on entropy generation, specifically contribution of heat transfer coefficient (HTC) and total pressure drop (TPD) on entropy generation for all testing tubes. As at a heat flux of 6 kW<middle dot>m(-)(2) and a saturation temperature of 12 degrees C, MFT1 shows HTC contributions to entropy generation ranging from 0.032 to 0.156 W<middle dot>K-1, while MFT2 ranges from 0.03 to 0.14 W<middle dot>K-1. TPD contributions for both MFT1 and MFT2 range from 0.001 to 0.04 W<middle dot>K-1. Hence, MFT2 shows better results than MFT1 as low entropy generation required for a good heat exchanger. Among input parameters, heat flux displays the highest sensitivity, indicating its significant influence on total entropy generation variations, while vapor quality, mass flux, and saturation temperature also demonstrate notable sensitivity. This research helps us design systems that transfer heat more effectively while using less energy. Understanding these factors can lead to more efficient heat exchangers and other thermal systems.