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- [21] A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at ChromatinJOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (16) : 8465 - 8474Sankaran, Saumya M.论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USAWilkinson, Alex W.论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USAElias, Joshua E.论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USAGozani, Or论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USA
- [22] Knockdown of NSD2 Suppresses Renal Cell Carcinoma Metastasis by Inhibiting Epithelial-Mesenchymal TransitionINTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2019, 16 (10): : 1404 - 1411Han, Xu论文数: 0 引用数: 0 h-index: 0机构: Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R China Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R ChinaPiao, Lianhua论文数: 0 引用数: 0 h-index: 0机构: Jiangsu Univ Technol, Inst Bioinformat & Med Engn, Changzhou 213001, Peoples R China Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R ChinaYuan, Xiaofeng论文数: 0 引用数: 0 h-index: 0机构: Soochow Univ, Affiliated Hosp 3, Dept Orthopaed, Changzhou 213003, Peoples R China Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R ChinaWang, Luhui论文数: 0 引用数: 0 h-index: 0机构: Soochow Univ, Affiliated Hosp 3, Dept Orthopaed, Changzhou 213003, Peoples R China Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R ChinaLiu, Zhiwei论文数: 0 引用数: 0 h-index: 0机构: Soochow Univ, Affiliated Hosp 3, Dept Orthopaed, Changzhou 213003, Peoples R China Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R ChinaHe, Xiaozhou论文数: 0 引用数: 0 h-index: 0机构: Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R China Soochow Univ, Dept Urol, Affiliated Hosp 3, Changzhou 213003, Peoples R China
- [23] A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic LeukemiaBLOOD, 2018, 132Li, Jianping论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USATroche, Catalina论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USASwaroop, Alok论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USAKulis, Marta论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USAOyer, Jon论文数: 0 引用数: 0 h-index: 0机构: Northwestern Univ, Chicago, IL 60611 USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USAWill, Christine论文数: 0 引用数: 0 h-index: 0机构: Northwestern Univ, Chicago, IL 60611 USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USADupere-Richer, Daphne论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USARiva, Alberto论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USAPipe, Crissandra论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USANorton, Sharon论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USABennett, Richard Lynn论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USALicht, Jonathan D.论文数: 0 引用数: 0 h-index: 0机构: Univ Florida, Canc Genet Res Complex, Gainesville, FL USA Univ Florida, Canc Genet Res Complex, Gainesville, FL USA
- [24] Role of mast cell tryptase in renal interstitial fibrosisJOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2001, 12 (08): : 1668 - 1676Kondo, S论文数: 0 引用数: 0 h-index: 0机构: Univ Tokushima, Sch Med, Dept Pediat, Tokushima 7708503, JapanKagami, S论文数: 0 引用数: 0 h-index: 0机构: Univ Tokushima, Sch Med, Dept Pediat, Tokushima 7708503, JapanKido, H论文数: 0 引用数: 0 h-index: 0机构: Univ Tokushima, Sch Med, Dept Pediat, Tokushima 7708503, JapanStrutz, F论文数: 0 引用数: 0 h-index: 0机构: Univ Tokushima, Sch Med, Dept Pediat, Tokushima 7708503, JapanMüller, GA论文数: 0 引用数: 0 h-index: 0机构: Univ Tokushima, Sch Med, Dept Pediat, Tokushima 7708503, JapanKuroda, Y论文数: 0 引用数: 0 h-index: 0机构: Univ Tokushima, Sch Med, Dept Pediat, Tokushima 7708503, Japan
- [25] Conditional knockout of the NSD2 gene in mouse intestinal epithelial cells inhibits colorectal cancer progressionAnimal Models and Experimental Medicine, 2025, 8 (02) : 322 - 331Mengyuan Li论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeHanxue Chen论文数: 0 引用数: 0 h-index: 0机构: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeXingjiu Yang论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeWenlong Zhang论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeChengyan Ma论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeQinghong Wang论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeXinpei Wang论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical CollegeRan Gao论文数: 0 引用数: 0 h-index: 0机构: National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases National Human Diseases Animal Model Resource Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College
- [26] Conditional knockout of the NSD2 gene in mouse intestinal epithelial cells inhibits colorectal cancer progressionANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2025, 8 (02) : 322 - 331Li, Mengyuan论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaChen, Hanxue论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Inst Basic Med Sci, Sch Basic Med, Peking Union Med Coll, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaYang, Xingjiu论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaZhang, Wenlong论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaMa, Chengyan论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaWang, Qinghong论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaWang, Xinpei论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R ChinaGao, Ran论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, NHC Key Lab Human Dis Comparat Med, Beijing, Peoples R China Beijing Engn Res Ctr Expt Anim Models Human Crit, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Human Dis Anim Model Resource Ctr, Inst Lab Anim Sci, Beijing, Peoples R China
- [27] Targeting NSD2 to reverse lineage plasticity and drug resistance in neuroendocrine prostate cancer and subtypes of mCRPCCANCER RESEARCH, 2024, 84 (06)Li, Jia J.论文数: 0 引用数: 0 h-index: 0Vasciaveo, Alessandro论文数: 0 引用数: 0 h-index: 0Karagiannis, Dimitrios论文数: 0 引用数: 0 h-index: 0Chen, Xiao论文数: 0 引用数: 0 h-index: 0Yu, Chen论文数: 0 引用数: 0 h-index: 0Califano, Andrea论文数: 0 引用数: 0 h-index: 0Lu, Chao论文数: 0 引用数: 0 h-index: 0Shen, Michael M.论文数: 0 引用数: 0 h-index: 0
- [28] Curcumin attenuates renal interstitial fibrosis by regulating autophagy and retaining mitochondrial function in unilateral ureteral obstruction ratsBASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 128 (04) : 594 - 604Lu, Miaomiao论文数: 0 引用数: 0 h-index: 0机构: Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R China Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R ChinaLi, Hang论文数: 0 引用数: 0 h-index: 0机构: Jinzhou Med Univ, Dept Radiotherapy, Affiliated Hosp 1, Jinzhou, Peoples R China Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R ChinaLiu, Wenlin论文数: 0 引用数: 0 h-index: 0机构: Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R China Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R ChinaZhang, Xuemei论文数: 0 引用数: 0 h-index: 0机构: Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R China Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R ChinaLi, Lili论文数: 0 引用数: 0 h-index: 0机构: Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R China Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R ChinaZhou, Hongli论文数: 0 引用数: 0 h-index: 0机构: Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R China Jinzhou Med Univ, Dept Nephrol, Affiliated Hosp 1, Jinzhou 121000, Peoples R China
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- [30] Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid TumorsJOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (18) : 16072 - 16087Yang, Chunju论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaLi, Bang论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaFeng, Zongbo论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaLi, Huaxuan论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaYang, Hong论文数: 0 引用数: 0 h-index: 0机构: Lingang Lab, Shanghai 200031, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaYang, Zhenjiao论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaLiu, Li论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaShi, Qiongyu论文数: 0 引用数: 0 h-index: 0机构: Lingang Lab, Shanghai 200031, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaWang, Hong论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China State Key Lab Antiinfect Drug Dev, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaChen, Zhong-Zhu论文数: 0 引用数: 0 h-index: 0机构: Chongqing Univ Arts & Sci, Coll Pharm, Natl & Local Joint Engn Res Ctr Targeted & Innovat, Chongqing 402160, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaHuang, Xun论文数: 0 引用数: 0 h-index: 0机构: Lingang Lab, Shanghai 200031, Peoples R China ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaWang, Junjian论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China State Key Lab Antiinfect Drug Dev, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R ChinaWang, Yuanxiang论文数: 0 引用数: 0 h-index: 0机构: Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China State Key Lab Antiinfect Drug Dev, Guangzhou 510006, Peoples R China Sun Yat Sen Univ, Sch Pharmaceut Sci, Balance Based Drug Discovery Lab, Guangzhou 510006, Peoples R China