Research on Water-Soluble Constituents and Anti-Aging Effect of the Leaves of Nelumbo nucifera Gaertn

被引：0
|
作者：
Cheng, Rong-Qian [1 ]
Zhang, Heyanhao [1 ]
Chang, Jun [1 ]
机构：
[1] Fudan Univ, Human Phenome Inst, Sch Pharm, 825 Zhangheng Rd, Shanghai 201023, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2024年 / 19卷 / 08期
关键词：
Nelumbo nucifera; water-soluble constituents; structure determination; flavonoids; anti-aging activity; ANTIOXIDANT ACTIVITY;
D O I：
10.1177/1934578X241271623
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Objective: This study aimed to isolate and elucidate the structure of water-soluble constituents from Nelumbo nucifera Gaertn. leaves and evaluate their anti-aging effect. Methods: The natural products were isolated from the 60% aqueous acetone extract of the leaves of N. nucifera by column chromatography on MCI gel CHP 20P, YMC-Gel ODS-AQ-HG, and TSK gel Toyopearl HW-40F. Their structures were elucidated using high-resolution-electrospray ionization-mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, and electronic circular dichroism spectroscopy. The anti-aging activity was evaluated in the Caenorhabditis elegans model. Results/Conclusion: One novel flavonoid nuciferanoid (1), together with eleven known compounds, were isolated from the extract of the leaves of N. nucifera. Among them, compound 1 could be a starting point for further development of anti-aging drugs.
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页数：5
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