Lysosomal control of the cGAS-STING signaling

被引：3
|
作者：
Xu, Yinfeng [1 ]
Wan, Wei [2 ,3 ]
机构：
[1] Hunan First Normal Univ, Lab Basic Biol, Changsha, Peoples R China
[2] Zhejiang Univ, Sch Med, Dept Biochem, Hangzhou, Peoples R China
[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Thorac Surg, Hangzhou, Peoples R China
来源：
TRENDS IN CELL BIOLOGY | 2024年 / 34卷 / 08期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.tcb.2024.05.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway has a crucial role in combating pathogen infection. However, its aberrant activation is involved in several human disorders. Lysosomes are emerging as key negative regulators of cGAS-STING signaling. Here, we discuss the lysosomal control of cGAS-STING signaling and its implication in human disorders.
引用
收藏
页码：622 / 625
页数：4
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