Could Ocular Glands Be Infected by SARS-CoV-2?

被引：0
|
作者：
Bu, Jinghua [2 ]
Zhang, Minjie [2 ]
Zhang, Rongrong [2 ]
Sun, Le [2 ]
Chen, Zhenzong [1 ]
Wu, Yang [1 ]
机构：
[1] Fudan Univ, Zhongshan Hosp Xiamen, Xiamen 361006, Peoples R China
[2] Xiamen Univ, Xiangan Hosp, Eye Inst, Dept Ophthalmol,Sch Med,Fujian Prov Key Lab Ophtha, Xiamen 361102, Peoples R China
来源：
DISEASES | 2024年 / 12卷 / 08期
关键词：
ACE2; SARS-CoV-2; Meibomian gland; ocular gland; inflammation;
D O I：
10.3390/diseases12080169
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of the study was to investigate the expression levels of ACE2 in ocular glands and to investigate the effect of S protein on them. Male C57BL/6J mice were used for the experiments. The expression levels of ACE2 are highest in the Meibomian glands, followed by the conjunctiva, the cornea, and the lacrimal glands. Co-immunoprecipitation assays confirmed direct binding between ACE2 and S protein in ocular surface epithelia and Meibomian glands. CD45+ cell infiltration was found in the S protein treatment group, which was accompanied by upregulation of inflammation-related cytokines. There was also prominent cell apoptosis in the S protein treatment group. In conclusion, not only the cornea and the conjunctiva, but also the Meibomian glands express ACE2, and S protein could induce ocular surface epithelial cell and Meibomian gland cell inflammation and apoptosis.
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页数：10
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