ChCl:Urea deep eutectic solvent as a green media for one-pot, three-component catalyst-free synthesis of spiro-benzoxazole derivatives

被引:1
|
作者
Asilpour, Fatemeh [1 ]
Saberi, Dariush [1 ]
Hasaninejad, Alireza [1 ]
机构
[1] Persian Gulf Univ, Fac Nano & Bio Sci & Technol, Dept Chem, Bushehr 75169, Iran
关键词
Deep eutectic solvent; Choline chloride; Catalyst-free; Isatin; Dihydrobenzoxazole; Spiro-benzoxazoles; EFFICIENT; DIHYDROPYRIDINES; DESS;
D O I
10.1016/j.molliq.2024.125537
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
An efficient catalyst-free procedure is reported for the one-pot three-component synthesis of novel spirobenzoxazole derivatives via the condensation reaction of isatins, dihydrobenzoxazole compounds, and malono derivatives in ChCl:Urea deep eutectic solvent, as a green reaction medium. Spiro-benzoxazoles were easily extracted from the reaction mixture, by adding water, and isolated in good to excellent yields.
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页数:6
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