Impact of rosuvastatin on pulse-wave velocity in men with HIV at moderate cardiovascular risk

被引：1

作者：

Trevillyan, Janine M. ^{[1
,2
]}

Dart, Anthony ^{[3
]}

Paul, Eldho ^{[4
]}

Dewar, Elizabeth M. ^{[3
]}

Hall, Victoria G. ^{[5
]}

Hoy, Jennifer F. ^{[6
,7
]}

机构：

[1] Austin Hlth, Dept Infect Dis, 145 Studley Rd, Heidelberg, Vic 3086, Australia

[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Infect Dis, Melbourne, Vic, Australia

[3] Alfred Hlth, Dept Cardiol, Heidelberg, Vic, Australia

[4] Monash Univ, Sch Publ Hlth & Prevent Med, ANZIC RC, Melbourne, Vic, Australia

[5] Peter MacCallum Canc Ctr, Dept Infect Dis, Melbourne, Vic, Australia

[6] Alfred Hlth, Dept Infect Dis, Melbourne, Vic, Australia

[7] Monash Univ, Melbourne, Vic, Australia

来源：

AIDS | 2024年 / 38卷 / 11期

基金：

英国医学研究理事会;

关键词：

ARTERIAL; STIFFNESS;

D O I：

10.1097/QAD.0000000000003930

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This single-centre substudy of a double-blind, randomized, placebo-controlled trial aimed to determine the effect of 96 weeks of rosuvastatin on pulse wave velocity (PWV) in men (n = 55, 54 years) with HIV at moderate cardiovascular risk (Framingham risk score 10-15%). PWV increased in both rosuvastatin [0.54 m/s standard error of difference (SED) 0.26] and placebo [0.50 m/s (SED 0.26), P = 0.896] arms, leading to no difference in PWV at week 96 [rosuvastatin 9.40 m/s (SE 0.31); placebo 9.21 m/s (SE0.31), P = 0.676].

引用

页码：1722 / 1724

页数：3

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