Red Blood Cell-Like Poly(ethylene glycol) Particles: Influence of Particle Stiffness on Biological Behaviors

被引：0
|
作者：
Gao, Zhiliang [1 ]
Sun, Hongning [1 ]
Yang, Shuang [1 ]
Li, Mengqi [1 ]
Qi, Na [1 ]
Cui, Jiwei [1 ,2 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Key Lab Colloid & Interface Chem, Minist Educ, Jinan 250100, Shandong, Peoples R China
[2] Shandong Univ, Shandong Key Lab Targeted Drug Delivery & Adv Phar, Jinan 250100, Shandong, Peoples R China
来源：
ACS MACRO LETTERS | 2024年 / 13卷 / 08期
基金：
中国国家自然科学基金;
关键词：
ARTIFICIAL CELLS; NANOPARTICLES;
D O I：
10.1021/acsmacrolett.4c00330
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Cell-like particles represent a category of synthetic particles designed to emulate the structures or functions of natural cells. Herein, we present the assembly of cell-like poly(ethylene glycol) (PEG) particles with different stiffnesses and shapes via replication of animal cells and investigate the impact of particle stiffness on their biological behaviors. As a proof of concept, we fabricate red blood cell-like and spherical PEG particles with varying cross-linking densities. A systematic exploration of their properties, encompassing morphology, stiffness, deformability, and biodistribution, reveal the vital influence of particle stiffness on in vivo fate, elucidating its role in governing the traversal of capillaries and the dynamic interactions with phagocytic cells.
引用
收藏
页码：966 / 971
页数：6
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