Long-term outcomes and quality of life in patients with Hirschsprung disease

被引:0
|
作者
Pakarinen, Mikko P. [1 ]
Mutanen, Annika [1 ]
机构
[1] Univ Helsinki, Childrens Hosp, Dept Pediat Surg, Helsinki, Finland
关键词
Adolescent Health; Colorectal Surgery; Gastroenterology; ENDORECTAL PULL-THROUGH; TOTAL COLONIC AGANGLIONOSIS; URINARY-TRACT SYMPTOMS; BOWEL FUNCTION; SEXUAL FUNCTION; ANORECTAL-MALFORMATIONS; FUNCTIONAL OUTCOMES; FECAL INCONTINENCE; CHILDREN; SURGERY;
D O I
10.1136/wjps-2024-000859
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Although patients with Hirschsprung disease are mostly affected by imperfect bowel function and fecal control in the long term, they are also predisposed to lower urinary tract symptoms, impaired sexual functions, infertility, psychosocial issues, and decreased quality of life. Rare, but notable comorbidities, which may manifest after childhood, include inflammatory bowel disease and familial medullary thyroid cancer. Despite frequent occurrence of fecal incontinence and constipation, the overall long-term outlook is quite optimistic as social continence with a good quality of life can be achieved by efficient bowel management also in those affected patients, whose self-coping strategies and medical treatment remain insufficient. Bowel dysfunction and other potential long-term complications are best managed by an interdisciplinary specialized approach not overlooking psychosocial issues, which also helps to correctly identify areas requiring continuing input by adult healthcare for young adult patients after transition. Additional research is needed to unravel the pathophysiological mechanisms of the long-term bowel dysfunction to identify novel therapeutic targets for development of more efficient innovative management strategies and thereby improvement of quality of life.
引用
收藏
页数:6
相关论文
共 50 条
  • [11] Long-Term Outcomes and Quality of Life in Patients after Soave Pull-Through Operation for Hirschsprung's Disease: An Observational Retrospective Study
    Viet Quoc Tran
    Mahler, Tania
    Dassonville, Martine
    Dinh Quang Truong
    Robert, Annie
    Goyens, Philippe
    Steyaert, Henri
    [J]. EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 2018, 28 (05) : 445 - 454
  • [12] Long-term functional outcomes in patients with Hirschsprung's disease with different lengths of the aganglionosis
    Verkuijl, Sanne
    Meinds, Rob
    Trzpis, Monika
    Broens, Paul
    [J]. NEUROGASTROENTEROLOGY AND MOTILITY, 2020, 32
  • [13] Long-term functional outcomes of patients with Hirschsprung disease following pull-through
    Theodora Gunadi
    Ezzah Fatmala Monica Carissa
    Dicky Stevie
    Kristy Daulay
    Andi Yulianda
    [J]. BMC Pediatrics, 22
  • [14] Long-term functional outcomes of patients with Hirschsprung disease following pull-through
    Gunadi
    Monica Carissa, Theodora
    Stevie
    Daulay, Ezzah Fatmala
    Yulianda, Dicky
    Iskandar, Kristy
    Dwihantoro, Andi
    [J]. BMC PEDIATRICS, 2022, 22 (01)
  • [15] Clinical outcome and long-term quality of life after surgical correction of Hirschsprung's disease
    Moore, SW
    Albertyn, R
    Cywes, S
    [J]. JOURNAL OF PEDIATRIC SURGERY, 1996, 31 (11) : 1496 - 1502
  • [16] Long-term Outcome of Hirschsprung Disease: Impact on Quality of Life and Social Condition at Adult Age
    Drissi, Farouk
    Meurette, Guillaume
    Baayen, Corine
    Wyart, Vincent
    Cretolle, Celia
    Guinot, Audrey
    Podevin, Guillaume
    Lehur, Paul-Antoine
    [J]. DISEASES OF THE COLON & RECTUM, 2019, 62 (06) : 727 - 732
  • [17] Long-term outcomes and quality of life after subtotal colectomy combined with modified Duhamel procedure for adult Hirschsprung's disease
    Wang, Lin
    He, Qi
    Jiang, Jun
    Li, Ning
    [J]. PEDIATRIC SURGERY INTERNATIONAL, 2014, 30 (01) : 55 - 61
  • [18] Long-term outcomes and quality of life after subtotal colectomy combined with modified Duhamel procedure for adult Hirschsprung’s disease
    Lin Wang
    Qi He
    Jun Jiang
    Ning Li
    [J]. Pediatric Surgery International, 2014, 30 : 55 - 61
  • [19] Long-term outcomes and quality of life following parotidectomy for benign disease
    Plath, Michaela
    Sand, Matthias
    Cavaliere, Carlo
    Plinkert, Peter K.
    Baumann, Ingo
    Zaoui, Karim
    [J]. ACTA OTORHINOLARYNGOLOGICA ITALICA, 2022, 42 (03) : 215 - 222
  • [20] Long-term surgical and patient-reported outcomes of Hirschsprung Disease
    Davidson, Joseph R.
    Kyrklund, Kristiina
    Eaton, Simon
    Pakarinen, Mikko P.
    Thompson, David S.
    Cross, Kate
    Blackburn, Simon C.
    De Coppi, Paolo
    Curry, Joe
    [J]. JOURNAL OF PEDIATRIC SURGERY, 2021, 56 (09) : 1502 - 1511