An induced pluripotent stem cell-based approach for hair follicle development and regeneration

被引：0

作者：

Sivamani, Poornima ^{[1
]}

Rajendran, Ramya Lakshmi ^{[2
]}

Gangadaran, Prakash ^{[2
,3
]}

Ahn, Byeong-Cheol ^{[2
,3
,4
]}

机构：

[1] Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore, India

[2] Kyungpook Natl Univ, Sch Med, Dept Nucl Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea

[4] Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea

来源：

REGENERATIVE THERAPY | 2024年 / 26卷

基金：

新加坡国家研究基金会;

关键词：

Hair loss; iPSCs; Hair follicle regeneration; Organoids; 3D culture; GENERATION; THERAPY;

D O I：

10.1016/j.reth.2024.07.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Because hair loss is a common concern for many individuals, potential regenerative therapies of hair follicles have been extensively researched. Induced pluripotent stem cells (iPSCs) are a promising avenue for hair follicle regeneration. This review explores current iPSC-based approaches and highlights their potential applications and challenges in hair restoration. The principles of iPSC technology, iPSC differentiation into hair follicle precursor cells, and potential clinical implications for hair follicle regeneration are also discussed. This overview of iPSCs and their applications aims to contribute to our understanding of their role in hair restoration and potential future therapeutic applications. (c) 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

引用

页码：502 / 507

页数：6

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