Biomedical Metal-Organic framework materials on antimicrobial therapy: Perspectives and challenges

As a barrier between the structure of the human body's internal organs and the outside environment, the skin serves crucial physiological tasks like protection, regulation, and metabolism. The skin's close interaction with the outside makes it particularly vulnerable to many injuries. Bacterial infections cause wound healing to take longer, raise the risk of chronic harm, and serve as a breeding ground for drug-resistant bacteria. As a result, it is critical to eliminate bacterial species from the wound region rapidly and efficiently. Metal-organic frameworks (MOFs), are critically adjustable hybrid materials that integrate organic ligands with coordination metals to generate a range of topologically isomorphic structures. MOFs' creation and shape are investigated by the metal source and ligand utilized in the reaction process, and the structural benefits of this near-infinite combination of structures allow boundless potential for their surface functionalization. MOF has a large effective surface area, tunable structure, adaptability, excellent biodegradability, high drug load, adjustable release of drugs, robust targeting, etc. It can be loaded with therapeutic materials and has programmability. It is more conducive to treating complex wounds while realizing the synergistic effects of antibacterial, anti-inflammatory, and proangiogenesis, effectively improving treatment safety. This review summarizes the most recent research advances on various MOFs for antimicrobial therapy, using diverse types of metal-ion-based MOFs as an entry point. Finally, it covers several important challenges in the antimicrobial treatment of metal-ion-based MOFs.