Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia

被引：1
|
作者：
Kumar, Ami [1 ,2 ,3 ]
Matulis, Kristen l. [1 ,2 ,3 ]
Fadel, Zena a. [3 ,4 ]
Fanning, Alexander s. [1 ,2 ,3 ]
Lang, Christian j. am [1 ,2 ,3 ,5 ,6 ]
Kuo, Sheng-han [1 ,2 ,3 ]
机构：
[1] Columbia Univ, Dept Neurol, 650 168th St,Room 305, New York, NY 10032 USA
[2] New York Presbyterian Hosp, New York, NY USA
[3] Columbia Univ, Irving Med Ctr, Initiat Columbia Ataxia & Tremor, New York, NY USA
[4] Columbia Univ, Teachers Coll, New York, NY USA
[5] Univ Irving Med Ctr, New York, NY USA
[6] SUNY Downstate, Dept Neurol, Brooklyn, NY USA
来源：
TREMOR AND OTHER HYPERKINETIC MOVEMENTS | 2024年 / 14卷
基金：
美国国家卫生研究院;
关键词：
DBS; low-frequency stimulation; caudal zona incerta; cerebellar ataxia; NUCLEUS;
D O I：
10.5334/tohm.925
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Whether low-frequency deep brain stimulation (DBS) in the caudal zona incerta (cZi) can improve cerebellar ataxia symptoms remains unexplored. Case Report: We report a 66-year-old man initially diagnosed with essential tremor and subsequently developed cerebellar ataxia after bilateral cZi DBS implantation. We tested the effects of low-frequency DBS stimulations (sham, 10 Hz, 15 Hz, 30 Hz) on ataxia severity. Discussion: Low-frequency cZi DBS improves ataxic speech at 30 Hz, but not at 10 Hz or 15 Hz in this patient. Low-frequency DBS did not improve gait or stance. Therefore, low- frequency stimulation may play a role in treating ataxic speech. Highlights The finding of this case study suggests that bilateral low-frequency DBS at 30 Hz in the caudal zona incerta has the potential to improve ataxic speech but has limited impact on gait and stance. The involvement of zona incerta in speech warrants further investigation.
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页码：1 / 8
页数：8
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