The role of cystathionine β-synthase in cancer

被引:2
|
作者
Wang, Yan-Wen [1 ]
Chu, Ti [1 ]
Wang, Xue-Li [1 ]
Fan, Yong-Qi [1 ]
Cao, Lei [1 ]
Chen, Yu-Hang [1 ]
Zhu, Yi-Wen [1 ]
Liu, Hong-Xia [1 ,2 ]
Ji, Xin-Ying [1 ,3 ]
Wu, Dong-Dong [1 ,2 ]
机构
[1] Henan Univ, Sch Basic Med Sci, Sch Stomatol, Henan Int Joint Lab Nucl Prot Regulat, Kaifeng 475004, Henan, Peoples R China
[2] Henan Univ, Huaihe Hosp, Sch Stomatol, Dept Stomatol, Kaifeng 475004, Henan, Peoples R China
[3] Shu Qing Med Coll Zhengzhou, Fac Basic Med Subjects, Zhengzhou 450064, Henan, Peoples R China
基金
中国国家自然科学基金;
关键词
Cystathionine beta-synthase; Hydrogen sulfide; CBS inhibitor; Cancer; Signaling pathway; HYDROGEN-SULFIDE PROTECTS; S-ADENOSYLMETHIONINE SAM; OXIDATIVE STRESS; LIVER-CANCER; IN-VITRO; MITOCHONDRIAL BIOGENESIS; METHIONINE METABOLISM; SODIUM HYDROSULFIDE; CHEMICAL BIOLOGY; STRUCTURAL BASIS;
D O I
10.1016/j.cellsig.2024.111406
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cystathionine beta-synthase (CBS) occupies a key position as the initiating and rate-limiting enzyme in the sulfur transfer pathway and plays a vital role in health and disease. CBS is responsible for regulating the metabolism of cysteine, the precursor of glutathione (GSH), an important antioxidant in the body. Additionally, CBS is one of the three enzymes that produce hydrogen sulfide (H2S) in mammals through a variety of mechanisms. The dysregulation of CBS expression in cancer cells affects H2S production through direct or indirect pathways, thereby influencing cancer growth and metastasis by inducing angiogenesis, facilitating proliferation, migration, and invasion, modulating cellular energy metabolism, promoting cell cycle progression, and inhibiting apoptosis. It is noteworthy that CBS expression exhibits complex changes in different cancer models. In this paper, we focus on the CBS synthesis and metabolism, tissue distribution, potential mechanisms influencing tumor growth, and relevant signaling pathways. We also discuss the impact of pharmacological CBS inhibitors and silencing CBS in preclinical cancer models, supporting their potential as targeted cancer therapies.
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收藏
页数:13
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