Enhancing survival after ionizing radiation exposure through mitigation of pyroptosis

被引：1
|
作者：
Richter, Brandon [1 ,3 ,4 ]
Epperly, Michael [2 ]
Tyurina, Yulia [1 ]
Shurin, Galina [1 ]
Johnson, Carla [3 ,4 ]
Korkmaz, Aybike [1 ,3 ,4 ,5 ,6 ]
Gao, Yuan [3 ,4 ]
Scott, Julie [3 ,4 ]
Greenberger, Joel [2 ]
Kagan, Valerian [1 ,4 ,5 ]
Bayir, Huelya [1 ,3 ,4 ,5 ]
机构：
[1] Univ Pittsburgh, Sch Publ Hlth, Ctr Free Rad & Antioxidant Hlth, Dept Environm & Occupat Hlth, 130 Desoto St, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Med Ctr, Dept Radiat Oncol, 200 Lothrop St, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Med Ctr, Safar Ctr Resuscitat Res, Dept Crit Care Med, 4401 Penn Ave, Pittsburgh, PA 15224 USA
[4] UPMC Childrens Hosp Pittsburgh, Childrens Neurosci Inst, 4401 Penn Ave, Pittsburgh, PA 15224 USA
[5] Columbia Univ Irving Med Ctr, Div Crit Care Hosp Med, Vagelos Coll Phys & Surg, Redox Hlth Ctr,Dept Pediat, New York, NY 10032 USA
[6] Ankara Univ, Grad Sch Hlth Sci, Dept Interdisciplinary Neurosci, Ankara, Turkiye
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 07期
关键词：
Pyroptosis; Radiation; Inflammation; Cell Death; Pharmacology; Immunology; CELL-DEATH; TOXICITY;
D O I：
10.1016/j.bbadis.2024.167434
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
center dot Pyroptosis is implicated in the pathogenesis of ionizing radiation so we investigated cell type involvement in a mouse model. center dot Pyroptotic markers were expressed highly at day 3 post total body irradiation (TBI) predominantly in immune cells from ileum. center dot We investigated the effectiveness of MCC950, a pyroptosis inhibitor, in our model showing survival benefit at 50 mg/kg. center dot Treatment with MCC950 showed elevation in full-length mediator IL-1(3 in ileum and decreased level of cleaved IL-1(3 in spleen.
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页数：4
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