Enhancing survival after ionizing radiation exposure through mitigation of pyroptosis

被引：1

作者：

Richter, Brandon ^{[1
,3
,4
]}

Epperly, Michael ^{[2
]}

Tyurina, Yulia ^{[1
]}

Shurin, Galina ^{[1
]}

Johnson, Carla ^{[3
,4
]}

Korkmaz, Aybike ^{[1
,3
,4
,5
,6
]}

Gao, Yuan ^{[3
,4
]}

Scott, Julie ^{[3
,4
]}

Greenberger, Joel ^{[2
]}

Kagan, Valerian ^{[1
,4
,5
]}

Bayir, Huelya ^{[1
,3
,4
,5
]}

机构：

[1] Univ Pittsburgh, Sch Publ Hlth, Ctr Free Rad & Antioxidant Hlth, Dept Environm & Occupat Hlth, 130 Desoto St, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Med Ctr, Dept Radiat Oncol, 200 Lothrop St, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Med Ctr, Safar Ctr Resuscitat Res, Dept Crit Care Med, 4401 Penn Ave, Pittsburgh, PA 15224 USA

[4] UPMC Childrens Hosp Pittsburgh, Childrens Neurosci Inst, 4401 Penn Ave, Pittsburgh, PA 15224 USA

[5] Columbia Univ Irving Med Ctr, Div Crit Care Hosp Med, Vagelos Coll Phys & Surg, Redox Hlth Ctr,Dept Pediat, New York, NY 10032 USA

[6] Ankara Univ, Grad Sch Hlth Sci, Dept Interdisciplinary Neurosci, Ankara, Turkiye

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 07期

关键词：

Pyroptosis; Radiation; Inflammation; Cell Death; Pharmacology; Immunology; CELL-DEATH; TOXICITY;

D O I：

10.1016/j.bbadis.2024.167434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

center dot Pyroptosis is implicated in the pathogenesis of ionizing radiation so we investigated cell type involvement in a mouse model. center dot Pyroptotic markers were expressed highly at day 3 post total body irradiation (TBI) predominantly in immune cells from ileum. center dot We investigated the effectiveness of MCC950, a pyroptosis inhibitor, in our model showing survival benefit at 50 mg/kg. center dot Treatment with MCC950 showed elevation in full-length mediator IL-1(3 in ileum and decreased level of cleaved IL-1(3 in spleen.

引用

页数：4

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