Hypoglycemic Effect of Polysaccharides from Physalis alkekengi L. in Type 2 Diabetes Mellitus Mice

被引:0
|
作者
Zhang, Yun [1 ]
Wang, Minghao [1 ]
Li, Peng [1 ]
Lv, Ge [1 ]
Yao, Jing [1 ]
Zhao, Lin [2 ]
机构
[1] Heilongjiang East Univ, Coll Food Engn, Harbin 150066, Peoples R China
[2] Heilongjiang Acad Agr Sci, Qual & Safety Inst Agr Prod, Harbin 150086, Peoples R China
来源
BIOLOGY-BASEL | 2024年 / 13卷 / 07期
关键词
type 2 diabetes mouse model; Physalis alkekengi L. polysaccharides; hypoglycemic; INFLAMMATION; EXTRACTION; STRESS; T2DM;
D O I
10.3390/biology13070496
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Type 2 diabetes mellitus (T2DM) is a common metabolic disease that adversely impacts patient health. In this study, a T2DM model was established in ICR mice through the administration of a high-sugar and high-fat diet combined with the intraperitoneal injection of streptozotocin to explore the hypoglycemic effect of polysaccharides from Physalis alkekengi L. After six weeks of treatment, the mice in the high-dosage group (800 mg/kg bw) displayed significant improvements in terms of fasting blood glucose concentration, glucose tolerance, serum insulin level, insulin resistance, and weight loss (p < 0.05). The polysaccharides also significantly regulated blood lipid levels by reducing the serum contents of total triglycerides, total cholesterol, and low-density lipoproteins and increasing the serum content of high-density lipoproteins (p < 0.05). Furthermore, they significantly enhanced the hepatic and pancreatic antioxidant capacities, as determined by measuring the catalase and superoxide dismutase activities and the total antioxidant capacity (p < 0.05). The results of immunohistochemistry showed that the P. alkekengi polysaccharides can increase the expression of GPR43 in mice colon epithelial cells, thereby promoting the secretion of glucagon-like peptide-1. In summary, P. alkekengi polysaccharides can help to regulate blood glucose levels in T2DM mice and alleviate the decline in the antioxidant capacities of the liver and pancreas, thus protecting these organs from damage.
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页数:19
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