Risk factors for the development of Stevens-Johnson syndrome/toxic epidermal necrolysis following drug administration: a systematic review and meta-analysis

被引：0

作者：

Fathima, Samaah ^{[1
]}

Grainge, Matthew J. ^{[2
]}

Wainman, Hannah ^{[3
,4
]}

Swiderski, Mikolaj ^{[5
]}

Gran, Sonia ^{[5
]}

机构：

[1] Univ Nottingham, Sch Med, Nottingham, England

[2] Univ Nottingham, Sch Med, Lifespan & Populat Hlth, Nottingham, England

[3] Bristol Royal Infirm & Gen Hosp, Dermatol Dept, Bristol, England

[4] Univ Bristol, Bristol Med Sch, Bristol, England

[5] Univ Nottingham, Ctr Evidence Based Dermatol, Sch Med, Nottingham, England

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2024年 / 49卷 / 12期

关键词：

CUTANEOUS ADVERSE-REACTIONS; ANTIEPILEPTIC DRUGS;

D O I：

10.1093/ced/llae183

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) following drug administration. The study protocol was registered on PROSPERO. The PRISMA guidelines were followed. On 17 October 2022, a search, advised by a librarian, was conducted in MEDLINE and Embase. Five studies were pooled. We report that HIV and male gender may be risk factors for SJS/TEN; however, this review was limited by a low number and quality of included studies. We conclude that a well-designed, large population-based case-control study with an appropriate control group is required to assess risk factors for the development of drug-induced SJS/TEN.

引用

页码：1699 / 1704

页数：6

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