(R/S)-Ethyl 2-Acetoxy-4-phenyl-4H-chromene-3-carboxylate

被引：0
|
作者：
Petkova-Yankova, Nevena I. [1 ]
Koleva, Ana I. [1 ]
Nikolova, Rositca D. [1 ]
机构：
[1] Sofia Univ St Kl Ohridski, Fac Chem & Pharm, Sofia 1164, Bulgaria
来源：
MOLBANK | 2024年 / 2024卷 / 03期
关键词：
4H-chromens; coumarins; enol form; O-acylation;
D O I：
10.3390/M1875
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple protocol for the preparation of O-acylated enol form (R/S)-ethyl-2-acetoxy-4-phenyl-4H-chromene-3-carboxylate 5 was presented. The compound was characterized by H-1-, C-13-and DEPT135 NMR spectra, including {H-1,H-1} COSY, {H-1,C-13} HSQC, {H-1,C-13} HMBC, and 2D-NOESY spectra. The preferred regioselectivity for O-acylation of 3,4-dihydrocoumarin 5 in the presence of substituent in the 4th position in the chroman ring and accounting for the steric hindrance of the ester group in the 3rd place was confirmed.
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页数：5
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