Progressive multifocal leukoencephalopathy in sarcoidosis successfully treated with pembrolizumab

被引：0
|
作者：
Oztuerk, Gizem [1 ]
Tekeli, Elif Irem [1 ]
Erdogan, Seyda [1 ]
Peker, Elif [2 ]
Yucesan, Canan [1 ]
机构：
[1] Ankara Univ, Ibn i Sina Hosp, Sch Med, Dept Neurol, TR-06230 Ankara, Turkiye
[2] Ankara Univ, Ibni Sina Hosp, Sch Med, Dept Radiol, TR-06230 Ankara, Turkiye
来源：
JOURNAL OF NEUROVIROLOGY | 2024年 / 30卷 / 04期
关键词：
Pembrolizumab; Progressive multifocal leukoencephalopathy; JC Virus; PML with sarcoidosis; VIRUS;
D O I：
10.1007/s13365-024-01227-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Progressive multifocal leukoencephalopathy (PML) is a severe, demyelinating disease of the central nervous system caused by JC virus infection. The disease can be seen in sarcoidosis patients without additional risk factors. Here, we present an individual with PML secondary to sarcoidosis treated with 8 doses of pembrolizumab, a Programmed Cell-Death-1 (PD-1) Immune Checkpoint Inhibitor who showed significant improvement. This report illustrates the objective clinical and radiological improvement in a patient with PML due to sarcoidosis, and suggests further study of immune checkpoint inhibitors as a potential treatment for sarcoidosis patients with PML.
引用
收藏
页码：441 / 444
页数：4
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