Sex-Specific Differences in Kidney Function and Blood Pressure Regulation

被引：0
|
作者：
Stamellou, Eleni [1 ,2 ]
Sterzer, Viktor [1 ]
Alam, Jessica [1 ]
Roumeliotis, Stefanos [3 ]
Liakopoulos, Vassilios [3 ]
Dounousi, Evangelia [2 ]
机构：
[1] Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, D-52074 Aachen, Germany
[2] Univ Hosp Ioannina, Dept Nephrol, Ioannina 45500, Greece
[3] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Nephrol 2, Med Sch, Thessaloniki 54124, Greece
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 16期
关键词：
endothelin system; RAS; sex; androgen; estrogen; SPONTANEOUSLY HYPERTENSIVE-RATS; ANGIOTENSIN-CONVERTING ENZYME; EPITHELIAL SODIUM-CHANNEL; II-INDUCED HYPERTENSION; DUCT-SPECIFIC KNOCKOUT; HIGH-SALT DIET; GENDER-DIFFERENCES; ANDROGEN RECEPTOR; COLLECTING DUCT; ARTERIAL-PRESSURE;
D O I：
10.3390/ijms25168637
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Premenopausal women generally exhibit lower blood pressure and a lower prevalence of hypertension than men of the same age, but these differences reverse postmenopause due to estrogen withdrawal. Sexual dimorphism has been described in different components of kidney physiology and pathophysiology, including the renin-angiotensin-aldosterone system, endothelin system, and tubular transporters. This review explores the sex-specific differences in kidney function and blood pressure regulation. Understanding these differences provides insights into potential therapeutic targets for managing hypertension and kidney diseases, considering the patient's sex and hormonal status.
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页数：17
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