Deceased Organ Donor HTLV Screening Practices Postelimination of Universal Screening in the United States

被引:0
|
作者
Yamauchi, Junji [1 ,2 ,3 ]
Raghavan, Divya [1 ]
Imlay, Hannah [4 ]
Jweehan, Duha [1 ]
Oygen, Suayp [1 ]
Marineci, Silviana [1 ]
Remport, Adam [5 ]
Hall, Isaac E. [1 ]
Molnar, Miklos Z. [1 ]
机构
[1] Univ Utah, Spencer Fox Eccles Sch Med, Dept Internal Med, Div Nephrol & Hypertens, 30 North Mario Capecchi Dr,Room 3S143, Salt Lake City, UT 84112 USA
[2] St Marianna Univ, Inst Med Sci, Dept Rare Dis Res, Sch Med, Kawasaki, Japan
[3] St Marianna Univ, Sch Med, Div Neurol, Dept Internal Med, Kawasaki, Japan
[4] Univ Utah, Dept Internal Med, Div Infect Dis, Spencer Fox Eccles Sch Med, Salt Lake City, UT USA
[5] Semmelweis Univ, Dept Transplantat, Budapest, Hungary
来源
TRANSPLANTATION DIRECT | 2024年 / 10卷 / 10期
关键词
D O I
10.1097/TXD.0000000000001707
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Background. In the United States, universal screening for human T-lymphotropic virus (HTLV) in deceased organ donors was discontinued in 2009. Since then, the transplant guideline suggests considering targeted screening. However, the outcomes of this change in HTLV screening have not been evaluated. Methods. Using the Organ Procurement and Transplantation Network database between 2010 and 2022, we analyzed the HTLV antibody screening frequency and seroprevalence in potential deceased organ donors and their correlations with HTLV infection risks, including race and high-risk behaviors for blood-borne pathogen infection. Although targeted screening has not been established for HTLV, we hypothesized that screening rates should correlate with the proportions of donors with infection risk if screening is targeted. We also evaluated the organ utilization of HTLV-seropositive donors. Results. Of 130 284 potential organ donors, 22 032 (16.9%) were tested for HTLV antibody. The proportion of donors tested for HTLV varied between Organ Procurement Organizations (median [interquartile range], 3.8% [1.0%-23.2%]; range, 0.2%-99.4%) and was not correlated to HTLV infection risks. There were 48 seropositive donors (0.22%), and at least 1 organ from 42 of these donors (87.5%) was transplanted. The number of organs recovered and transplanted per donor was significantly lower in HTLV-seropositive than in HTLV-negative donors (recovered, 2 [2-3] versus 3 [3-5], P < 0.001; transplanted, 2 [1-3] versus 3 [2-4], P < 0.001). However, HTLV-1 infection was not attributed as the cause of nonrecovery except for only 1 HTLV-seropositive donor. Conclusions. HTLV screening practices varied across the United States. Our findings suggest that targeted screening was not performed after the elimination of universal screening.
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页数:14
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