Familial Acute Promyelocytic Leukemia: A Case Report and Review of the Literature

被引：0
|
作者：
Yang, Mingqi [1 ,2 ]
Bai, Lian [3 ]
Ma, Yunju [1 ,2 ]
Cao, Xuanqi [1 ,2 ]
Cui, Qingya [1 ,2 ]
Wu, Depei [1 ,2 ]
Tang, Xiaowen [1 ,2 ]
机构：
[1] Soochow Univ, Jiangsu Inst Hematol, Natl Clin Res Ctr Hematol Dis, Affiliated Hosp 1, Suzhou, Peoples R China
[2] Soochow Univ, Inst Blood & Marrow Transplantat, Collaborat Innovat Ctr Hematol, Suzhou, Peoples R China
[3] Canglang Hosp Suzhou, Suzhou, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2024年 / 17卷
基金：
中国国家自然科学基金;
关键词：
familial; acute promyelocytic leukemia; APL differentiation syndrome; hereditary predisposition; germline mutation; TERM-FOLLOW-UP; ARSENIC TRIOXIDE; PREDISPOSITION;
D O I：
10.2147/OTT.S482781
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation t (15;17) (q24;q21), which leads to the fusion of PML and RAR alpha genes known as PML-RAR alpha fusion. A few cases of potentially hereditary leukemia-related genes in APL have been reported, but no instances of familial aggregation of APL have been documented. Here, we describe a family in whom two members successively affected by APL The potential familial association observed in these two cases of APL highlights the need for further investigation and more definitive genetic lineage tracing in order to understand the genetic basis of this disease.
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页码：733 / 738
页数：6
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