Pharmacological Strategies and Surgical Management of Posthemorrhagic Hydrocephalus Following Germinal Matrix-Intraventricular Hemorrhage in Preterm Infants

被引:0
|
作者
Yang, Zhao [1 ,2 ]
Luo, Tian Tian [3 ]
Dai, Ya-Lan [1 ,2 ]
Duan, Han-Xiao [1 ,2 ]
Chong, Cheong-Meng [4 ]
Tang, Jun [1 ,2 ]
机构
[1] Chongqing Med Univ, Natl Res Ctr Child Hlth & Disorders, Dept Neurosurg, Childrens Hosp, Chongqing 400014, Peoples R China
[2] Chongqing Key Lab Translat Med Res Cognit Dev & Le, Chongqing 400014, Peoples R China
[3] Army Med Univ, Third Mil Med Univ, Dept Neurobiol, Chongqing 400038, Peoples R China
[4] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
基金
美国国家科学基金会;
关键词
Posthemorrhagic hydrocephalus; germinal matrix-intraventricular hemorrhage; preterm infants; molecular mechanisms; clinical study; low birth weight; ENDOSCOPIC 3RD VENTRICULOSTOMY; CEREBROSPINAL-FLUID DYNAMICS; PREMATURE-INFANTS; BRAIN-INJURY; NEURODEVELOPMENTAL OUTCOMES; ANTENATAL CORTICOSTEROIDS; FIBRINOLYTIC THERAPY; DILATATION; PATHOGENESIS; PREVENTION;
D O I
10.2174/1570159X23666240906115817
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Germinal matrix-intraventricular hemorrhage (GM-IVH) is a detrimental neurological complication that occurs in preterm infants, especially in babies born before 32 weeks of gestation and in those with a very low birth weight. GM-IVH is defined as a rupture of the immature and fragile capillaries located in the subependymal germinal matrix zone of the preterm infant brain, and it can lead to detrimental neurological sequelae such as posthemorrhagic hydrocephalus (PHH), cerebral palsy, and other cognitive impairments. PHH following GM-IVH is difficult to treat in the clinic, and no level-one strategies have been recommended to pediatric neurosurgeons. Several cellular and molecular mechanisms of PHH following GM-IVH have been studied in animal models, but no effective pharmacological strategies have been used in the clinic. Thus, a comprehensive understanding of molecular mechanisms, potential pharmacological strategies, and surgical management of PHH is urgently needed. The present review presents a synopsis of the pathogenesis, diagnosis, and cellular and molecular mechanisms of PHH following GM-IVH and explores pharmacological strategies and surgical management.
引用
收藏
页码:241 / 255
页数:15
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