Evaluation of Plasma Atherogenic Index, Triglyceride-Glucose Index and Other Lipid Ratios as Predictive Biomarkers of Coronary Artery Disease in Different Age Groups

被引:5
|
作者
Okan, Taha [1 ]
Doruk, Mehmet [2 ]
Ozturk, Ali [3 ]
Topaloglu, Caner [4 ]
Dogdus, Mustafa [4 ]
Yilmaz, Mehmet Birhan [5 ]
机构
[1] Kardiya Med Ctr, TR-35000 Izmir, Turkiye
[2] Izmir Endocrinol Clin, TR-35500 Izmir, Turkiye
[3] Ozel Saglik Int Hosp, Dept Cardiol, TR-35000 Izmir, Turkiye
[4] Izmir Econ Univ, Fac Med, Dept Cardiol, TR-35550 Izmir, Turkiye
[5] Dokuz Eylul Univ, Fac Med, Dept Cardiol, TR-35220 Izmir, Turkiye
关键词
premature coronary artery disease; plasma atherogenic index; triglyceride-glucose index; lipoproteins ratios; coronary computed tomography angiography; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; HEART-DISEASE; TG/HDL-C; INFLAMMATION; ASSOCIATION; PARAMETERS;
D O I
10.3390/diagnostics14141495
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: Dyslipidaemia and insulin resistance are major risk factors for coronary artery disease (CAD). This study investigated the relationship between plasma atherogenic index (PA-I), triglyceride-glucose index (TGI) and other lipid ratios with the presence and prediction of CAD among different age categories. (2) Methods: The study included 223 participants diagnosed with CAD and those with normal coronary arteries (normal group) by coronary computed tomography angiography (CCTA). Participants were categorised by age and sex: premature CAD (PCAD) for men under 55 and women under 65, and older groups as elderly. (3) Results: PA-I, Lipid Combined Index, Castelli Risk Indices, and TGI were significantly higher in the PCAD group compared to the control group (p < 0.05). ROC analysis showed that a PA-I cut-off of 0.41 had a sensitivity of 62% and a specificity of 58% for predicting PCAD, while a TGI cut-off of 8.74 had a sensitivity of 68% and a specificity of 62%. In the elderly, no significant differences in these indices were found between the CAD and normal groups. (4) Conclusions: Traditional lipid profiles and non-traditional lipid indices such as PA-I and TGI show significant differences in predicting CAD in younger populations but not in older groups. TGI and PA-I may be promising biomarkers for the prediction of PAD, although further validation is needed.
引用
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页数:10
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