Modakafusp alfa shows intratumoral immune pharmacodynamics (PD) in a subset of patients (pts) in a phase 1b study in advanced/metastatic solid tumors

被引：0
|
作者：
Saggu, Gurpanna
Markman, Janet L.
Lee, Min Young
Dunbar, Faith
Joshi, Adarsh
Wang, Shining
Collins, Sabrina
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2024-CT065
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CT065
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Dose escalation of a phase 1b/2 study of modakafusp alfa, an immune-targeting attenuated cytokine, in patients (pts) with metastatic solid tumors
    Johnson, Melissa Lynne
    Abdul-Karim, Raghad
    Sommerhalder, David
    Hafez, Navid
    Wang, Shining
    Li, Cheryl
    Liu, Yuyin
    Yang, Lili
    Collins, Sabrina
    Parot, Xavier
    Strauss, James F.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [2] Phase 1b study of TAK-659+nivolumab (nivo) in patients (pts) with advanced solid tumors.
    Juric, Dejan
    Olszanski, Anthony J.
    Vaishampayan, Ulka N.
    Li, Cong
    Wang, Shining
    Shou, Yaping
    Rong, Yuanxin
    Nemunaitis, John
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [3] A phase 1b study to evaluate TAK-659 in combination with nivolumab in patients (pts) with advanced solid tumors.
    Juric, Dejan
    Faucette, Stephanie
    Wang, Ling
    Niu, Huifeng
    Kannan, Karuppiah
    Stump, Kate
    Rong, Yuanxin
    Shou, Yaping
    Nemunaitis, John J.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [4] Phase 1b/2 study of rebastinib (DCC-2036) in combination with paclitaxel: Preliminary safety, efficacy, pharmacokinetics and pharmacodynamics in patients with advanced or metastatic solid tumors
    Janku, Filip
    Birrer, Michael
    Richardson, Debra
    Chu, Christina
    Goel, Sanjay
    Su, Ying
    Matin, Bahar
    Kuida, Keisuke
    Ruiz-Soto, Rodrigo
    Hamilton, Erika Paige
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [5] Safety, pharmacokinetics (PK), and pharmacodynamics (PD) of AMG 706 in patients (pts) with advanced solid tumors
    Herbst, R.
    Kurzrock, R.
    Parson, M.
    Mulay, M.
    Purdom, M.
    Eschenberg, M.
    Wong, S.
    Xu, R.
    Wathen, L.
    Rosen, L.
    EJC SUPPLEMENTS, 2005, 3 (02): : 421 - 421
  • [6] A phase 1b/2 study of ramucirumab in combination with emibetuzumab in patients with advanced solid tumors
    Bendell, Johanna
    Fuchs, Charles
    Voss, Martin
    Bauer, Todd M.
    Choueiri, Toni K.
    Drilon, Alexander
    Thorn, Katharine
    Wijayawardana, Sameera
    Moser, Brian
    Urunuela, Arantxa
    Wacheck, Volker
    Harding, James J.
    CANCER RESEARCH, 2017, 77
  • [7] Evaluation of pharmacokinetics (PK) and pharmacodynamics (PD) of patupilone and warfarin in patients (pts) with advanced solid tumors: An open-label, phase I study
    Takimoto, C. H.
    Fu, S.
    Dhillon, N.
    Mita, M. M.
    Mita, A. C.
    Cheung, W.
    Xu, Y.
    Ali, A.
    Johri, A.
    Kurzrock, R.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [8] Phase 1b study of aldoxorubicin plus gemcitabine in metastatic solid tumors.
    Sankhala, Kamalesh Kumar
    Chawla, Shanta
    Chua, Victoria S.
    Sachdev, Jasgit C.
    Borazanci, Erkut Hasan
    Sung, Kelli
    Mita, Monica M.
    Mita, Alain C.
    Laabs, Brenda
    Wieland, Scott
    Levitt, Daniell.
    Chawla, Sant P.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [9] First-in-human phase 1/1b study to evaluate sitravatinib in patients with advanced solid tumors
    Bauer, Todd
    Cho, Byong Chul
    Heist, Rebecca
    Bazhenova, Lyudmila
    Werner, Theresa
    Goel, Sanjay
    Kim, Dong-Wan
    Adkins, Douglas
    Carvajal, Richard D.
    Alva, Ajjai
    Eaton, Keith
    Wang, Judy
    Liu, Yong
    Yan, Xiaohong
    Christensen, Jamie
    Neuteboom, Saskia
    Chao, Richard
    Pant, Shubham
    INVESTIGATIONAL NEW DRUGS, 2022, 40 (05) : 990 - 1000
  • [10] First-in-human phase 1/1b study to evaluate sitravatinib in patients with advanced solid tumors
    Todd Bauer
    Byong Chul Cho
    Rebecca Heist
    Lyudmila Bazhenova
    Theresa Werner
    Sanjay Goel
    Dong-Wan Kim
    Douglas Adkins
    Richard D. Carvajal
    Ajjai Alva
    Keith Eaton
    Judy Wang
    Yong Liu
    Xiaohong Yan
    Jamie Christensen
    Saskia Neuteboom
    Richard Chao
    Shubham Pant
    Investigational New Drugs, 2022, 40 : 990 - 1000
12345