The role of the hepatitis B virus genome and its integration in the hepatocellular carcinoma
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作者:
Li, Weiyang
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机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Li, Weiyang
[1
,2
]
Wang, Suhao
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Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Wang, Suhao
[2
]
Jin, Yani
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Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Jin, Yani
[2
]
Mu, Xiao
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Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Mu, Xiao
[2
]
Liu, Qingbin
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机构:
Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Liu, Qingbin
[3
,4
]
Cui, Xiaofang
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机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Cui, Xiaofang
[1
,2
]
机构:
[1] Jining Med Univ, Jining, Peoples R China
[2] Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R China
[3] Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
[4] Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R China
hepatitis B virus integration;
liver cancer;
genomic instability;
hepatitis B virus infection;
hepatitis B virus;
DOUBLE-STRAND BREAKS;
HBV INTEGRATION;
CIRCULAR DNA;
CLINICAL-FEATURES;
LIVER;
SEQUENCES;
REPAIR;
CELLS;
HOST;
EXPANSION;
D O I:
10.3389/fmicb.2024.1469016
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The integration of Hepatitis B Virus (HBV) is now known to be closely associated with the occurrence of liver cancer and can impact the functionality of liver cells through multiple dimensions. However, despite the detailed understanding of the characteristics of HBV integration and the mechanisms involved, the subsequent effects on cellular function are still poorly understood in current research. This study first systematically discusses the relationship between HBV integration and the occurrence of liver cancer, and then analyzes the status of the viral genome produced by HBV replication, highlighting the close relationship and structure between double-stranded linear (DSL)-HBV DNA and the occurrence of viral integration. The integration of DSL-HBV DNA leads to a certain preference for HBV integration itself. Additionally, exploration of HBV integration hotspots reveals obvious hotspot areas of HBV integration on the human genome. Virus integration in these hotspot areas is often associated with the occurrence and development of liver cancer, and it has been determined that HBV integration can promote the occurrence of cancer by inducing genome instability and other aspects. Furthermore, a comprehensive study of viral integration explored the mechanisms of viral integration and the internal integration mode, discovering that HBV integration may form extrachromosomal DNA (ecDNA), which exists outside the chromosome and can integrate into the chromosome under certain conditions. The prospect of HBV integration as a biomarker was also probed, with the expectation that combining HBV integration research with CRISPR technology will vigorously promote the progress of HBV integration research in the future. In summary, exploring the characteristics and mechanisms in HBV integration holds significant importance for an in-depth comprehension of viral integration.
机构:
Department of Pediatric, Gynecologic, Microbiological, and Biomedical Sciences, University Hospital of Messina, 98124 Messina, ItalyDepartment of Pediatric, Gynecologic, Microbiological, and Biomedical Sciences, University Hospital of Messina, 98124 Messina, Italy
Teresa Pollicino
Carlo Saitta
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Department of Clinical and Experimental Medicine, University Hospital of Messina, 98124 Messina, ItalyDepartment of Pediatric, Gynecologic, Microbiological, and Biomedical Sciences, University Hospital of Messina, 98124 Messina, Italy
机构:
Sichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Han, Ting-Ting
Huang, Ji-Hua
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Sichuan Jinxin Xinan Womens & Childrens Hosp, Med Genet Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Huang, Ji-Hua
Li, Ling-Xiao
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Sichuan Jinxin Xinan Womens & Childrens Hosp, Med Genet Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Li, Ling-Xiao
Liao, Xue
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Sichuan Jinxin Xinan Womens & Childrens Hosp, Med Genet Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Liao, Xue
Meng, Xiang-Qian
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Sichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Meng, Xiang-Qian
Wen, Zi-Na
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Sichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Wen, Zi-Na
Sun, Qian
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Sichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Sun, Qian
Ma, Jian
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机构:
Sichuan Jinxin Xinan Womens & Childrens Hosp, Med Lab, Chengdu, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China
Ma, Jian
Huang, Tian-Hua
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机构:
Chengdu Jinxin Res Inst Reprod Med & Genet, Chengdu, Peoples R China
Chengdu Jinxin Res Inst Reprod Med & Genet, Chengdu 610000, Sichuan, Peoples R ChinaSichuan Jinxin Xinan Womens & Childrens Hosp, Reprod Med Ctr, Chengdu, Peoples R China