The role of the hepatitis B virus genome and its integration in the hepatocellular carcinoma
被引:0
|
作者:
Li, Weiyang
论文数: 0引用数: 0
h-index: 0
机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Li, Weiyang
[1
,2
]
Wang, Suhao
论文数: 0引用数: 0
h-index: 0
机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Wang, Suhao
[2
]
Jin, Yani
论文数: 0引用数: 0
h-index: 0
机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Jin, Yani
[2
]
Mu, Xiao
论文数: 0引用数: 0
h-index: 0
机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Mu, Xiao
[2
]
Liu, Qingbin
论文数: 0引用数: 0
h-index: 0
机构:
Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Liu, Qingbin
[3
,4
]
Cui, Xiaofang
论文数: 0引用数: 0
h-index: 0
机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Cui, Xiaofang
[1
,2
]
机构:
[1] Jining Med Univ, Jining, Peoples R China
[2] Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R China
[3] Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
[4] Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R China
hepatitis B virus integration;
liver cancer;
genomic instability;
hepatitis B virus infection;
hepatitis B virus;
DOUBLE-STRAND BREAKS;
HBV INTEGRATION;
CIRCULAR DNA;
CLINICAL-FEATURES;
LIVER;
SEQUENCES;
REPAIR;
CELLS;
HOST;
EXPANSION;
D O I:
10.3389/fmicb.2024.1469016
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The integration of Hepatitis B Virus (HBV) is now known to be closely associated with the occurrence of liver cancer and can impact the functionality of liver cells through multiple dimensions. However, despite the detailed understanding of the characteristics of HBV integration and the mechanisms involved, the subsequent effects on cellular function are still poorly understood in current research. This study first systematically discusses the relationship between HBV integration and the occurrence of liver cancer, and then analyzes the status of the viral genome produced by HBV replication, highlighting the close relationship and structure between double-stranded linear (DSL)-HBV DNA and the occurrence of viral integration. The integration of DSL-HBV DNA leads to a certain preference for HBV integration itself. Additionally, exploration of HBV integration hotspots reveals obvious hotspot areas of HBV integration on the human genome. Virus integration in these hotspot areas is often associated with the occurrence and development of liver cancer, and it has been determined that HBV integration can promote the occurrence of cancer by inducing genome instability and other aspects. Furthermore, a comprehensive study of viral integration explored the mechanisms of viral integration and the internal integration mode, discovering that HBV integration may form extrachromosomal DNA (ecDNA), which exists outside the chromosome and can integrate into the chromosome under certain conditions. The prospect of HBV integration as a biomarker was also probed, with the expectation that combining HBV integration research with CRISPR technology will vigorously promote the progress of HBV integration research in the future. In summary, exploring the characteristics and mechanisms in HBV integration holds significant importance for an in-depth comprehension of viral integration.
机构:
INSERM, Equipe Pathogenese Hepatites Virales & Immunothe, F-75015 Paris, France
Univ Paris 05, Fac Med Necker, Sorbonne Paris Cite, F-75015 Paris, FranceINSERM, Equipe Pathogenese Hepatites Virales & Immunothe, F-75015 Paris, France
Quetier, Ivan
Kremsdorf, Dina
论文数: 0引用数: 0
h-index: 0
机构:
CIMI, Inserm U1135, Equipe Infect Viral Persistante, F-75013 Paris, France
Univ Paris 06, Sorbonne Univ, F-75252 Paris 05, FranceINSERM, Equipe Pathogenese Hepatites Virales & Immunothe, F-75015 Paris, France
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Jiang, Zhaoshi
Jhunjhunwala, Suchit
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Jhunjhunwala, Suchit
Liu, Jinfeng
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Liu, Jinfeng
Haverty, Peter M.
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Haverty, Peter M.
Kennemer, Michael I.
论文数: 0引用数: 0
h-index: 0
机构:
Complete Genom Inc, Mountain View, CA 94043 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Kennemer, Michael I.
Guan, Yinghui
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Guan, Yinghui
Lee, William
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Lee, William
Carnevali, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Complete Genom Inc, Mountain View, CA 94043 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Carnevali, Paolo
Stinson, Jeremy
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Stinson, Jeremy
Johnson, Stephanie
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Johnson, Stephanie
Diao, Jingyu
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Microbial Pathogenesis, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Diao, Jingyu
Yeung, Stacy
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Yeung, Stacy
Jubb, Adrian
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Jubb, Adrian
Ye, Weilan
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Ye, Weilan
Wu, Thomas D.
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Wu, Thomas D.
Kapadia, Sharookh B.
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Microbial Pathogenesis, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Kapadia, Sharookh B.
de Sauvage, Frederic J.
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
de Sauvage, Frederic J.
Gentleman, Robert C.
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Gentleman, Robert C.
Stern, Howard M.
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Stern, Howard M.
Seshagiri, Somasekar
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Seshagiri, Somasekar
Pant, Krishna P.
论文数: 0引用数: 0
h-index: 0
机构:
Complete Genom Inc, Mountain View, CA 94043 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Pant, Krishna P.
Modrusan, Zora
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Modrusan, Zora
Ballinger, Dennis G.
论文数: 0引用数: 0
h-index: 0
机构:
Complete Genom Inc, Mountain View, CA 94043 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA
Ballinger, Dennis G.
Zhang, Zemin
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USAGenentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA