Merging of Palladium and Organocatalysis Enabled Asymmetric Decarboxylative (2+1) Cycloadditions toward Cyclopropanes

被引：0

作者：

Yan, Biwei ^{[1
]}

Ma, Pengchen ^{[2
,3
]}

Shu, Xiao ^{[1
]}

Yin, Wenhao ^{[1
]}

Guo, Wusheng ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol FIST, Xian 710049, Peoples R China

[2] Xi An Jiao Tong Univ, Minist Educ, Sch Chem, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China

[3] Xi An Jiao Tong Univ, Minist Educ, Engn Res Ctr Energy Storage Mat & Devices, Xian 710049, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 20期

关键词：

C-BOND ACTIVATION; CATALYSIS; COMPLEXES; PK(A)S;

D O I：

10.1021/acs.orglett.4c01088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cascade reaction enabling enantio- and diastereoselective construction of strained cyclopropanes is described. This asymmetric (2+1) annulation process uses vinyl methylene carbonate and 2-cyanoacrylate as reaction partners in the presence of Pd(PPh3)(4) as a precatalyst and an enantioenriched phosphoramidite ligand featuring a morpholine functionality. Mechanistic investigations unveil that the PPh3 derived from the Pd(PPh3)(4) and the morpholine-containing phosphoramidite work as cooperative phosphorus and Br & oslash;nsted base catalysts to promote the reaction.

引用

页码：4274 / 4279

页数：6

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