Advances in therapeutic cancer vaccines: Harnessing immune adjuvants for enhanced efficacy and future perspectives

被引：0
|
作者：
Ren, Dekang [1 ,2 ]
Xiong, Shizheng [1 ,2 ]
Ren, Yujie [1 ,2 ]
Yang, Xueni [1 ,2 ]
Zhao, Xinmiao [1 ,2 ]
Jin, Jiaming [1 ,2 ]
Xu, Miaomiao [1 ,2 ]
Liang, Tingming [3 ]
Guo, Li [1 ,2 ]
Weng, Lixing [1 ,2 ]
机构：
[1] Nanjing Univ Posts & Telecommun, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China
[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Nanjing 210023, Peoples R China
[3] Nanjing Normal Univ, Sch Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Peoples R China
来源：
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2024年 / 23卷
关键词：
Adjuvants; Therapeutic cancer vaccines; In situ vaccination; Immunogenic cell death; IMMUNOGENIC CELL-DEATH; SENSITIZE TUMORS; FAMILY CYTOKINES; PROSTATE-CANCER; SIPULEUCEL-T; IMMUNOTHERAPY; DELIVERY; CD8(+); NANOMEDICINE; PREVENTION;
D O I：
10.1016/j.csbj.2024.04.054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Preventive cancer vaccines are highly effective in preventing viral infection-induced cancer, but advances in therapeutic cancer vaccines with a focus on eliminating cancer cells through immunotherapy are limited. To develop therapeutic cancer vaccines, the integration of optimal adjuvants is a potential strategy to enhance or complement existing therapeutic approaches. However, conventional adjuvants do not satisfy the criteria of clinical trials for therapeutic cancer vaccines. To improve the effects of adjuvants in therapeutic cancer vaccines, effective vaccination strategies must be formulated and novel adjuvants must be identified. This review offers an overview of the current advancements in therapeutic cancer vaccines and highlights in situ vaccination approaches that can be synergistically combined with other immunotherapies by harnessing the adjuvant effects. Additionally, the refinement of adjuvant systems using cutting-edge technologies and the elucidation of molecular mechanisms underlying immunogenic cell death to facilitate the development of innovative adjuvants have been discussed.
引用
收藏
页码：1833 / 1843
页数：11
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