Anti-Inflammatory Potential of Chalcone Related Compounds: An Updated Review

Inflammation is a physiological process that involves a variety of inflammatory mediators such as PGE2, Nitric oxides, PLA2 etc., blocking these mediators could be helpful in designing and development of promising anti-inflammatory compounds. Non-steroidal anti-inflammatory drugs (NSAIDs) have been used for the treatment of inflammatory-related disorders via variety of pathways that include inhibition of COX-1, COX-2, LOX, NO etc. Chalcone derivatives, characterized by their unique chemical structure, have emerged as potential candidates for modulating inflammatory pathways. Literature suggested that modifications in chalcone derivatives by targeting different molecular targets could leads to the development of potential anti-inflammatory agents. In this review, we have summarised representative chalcone derivatives against different anti-inflammatory targets and discussed their structure-activity relationship along with relevant data. This work explores the anti-inflammatory potential and structure activity relationship of chalcone derivatives. A literature has been classified as per their inflammatory targets that include cyclooxygenase inhibitors, lipoxygenase Inhibitors, inducible nitric oxide synthase and prostaglandin E2 inhibitors, tumor necrosis factor inhibitors, nuclear factor-kappa B inhibitors, Inhibition of miscellaneous inflammatory mediators. image