Muscarinic Receptors and Alzheimer's Disease: New Perspectives and Mechanisms

被引：2
|
作者：
Monaco, Martina [1 ]
Trebesova, Hanna [1 ]
Grilli, Massimo [1 ,2 ]
机构：
[1] Univ Genoa, Dept Pharm, Viale Cembrano 4, I-16148 Genoa, Italy
[2] Interuniv Ctr Promot 3Rs Principles Teaching & Res, I-16148 Genoa, Italy
来源：
CURRENT ISSUES IN MOLECULAR BIOLOGY | 2024年 / 46卷 / 07期
关键词：
Alzheimer's disease; muscarinic receptors; cholinergic transmission; neuroinflammation; innovative therapy; ACETYLCHOLINE-RECEPTOR; BINDING; DEFICITS; AGONIST; MEMORY; MODEL; NEUROINFLAMMATION; EXPRESSION; AROUSAL; PROTEIN;
D O I：
10.3390/cimb46070407
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases on a global scale. Historically, this pathology has been linked to cholinergic transmission, and despite the scarcity of effective therapies, numerous alternative processes and targets have been proposed as potential avenues for comprehending this complex illness. Nevertheless, the fundamental pathophysiological mechanisms underpinning AD remain largely enigmatic, with a growing body of evidence advocating for the significance of muscarinic receptors in modulating the brain's capacity to adapt and generate new memories. This review summarizes the current state of the art in the field of muscarinic receptors' involvement in AD. A specific key factor was the relationship between comorbidity and the emergence of new mechanisms.
引用
收藏
页码：6820 / 6835
页数：16
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