Environmental-genetic interactions in ageing and dementia across Latin America

被引：1

作者：

Ibanez, Agustin ^{[1
,2
]}

Slachevsky, Andrea ^{[3
,4
,5
,6
,7
,8
]}

机构：

[1] Univ Adolfo Ibanez, Latin Amer Brain Hlth Inst, Santiago, Chile

[2] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

[3] Geroscience Ctr Brain Hlth & Metab, Santiago, Chile

[4] Univ Chile, Hosp Salvador, Memory & Neuropsychiat Ctr, Neurol Dept, Santiago, Chile

[5] Univ Chile, Fac Med, Santiago, Chile

[6] Univ Chile, Inst Biomed Sci, Fac Med, Neuropsychol & Clin Neurosci Lab,Physiopathol Dept, Santiago, Chile

[7] Univ Chile, Inst Biomed Sci, Fac Med, Neuropsychol & Clin Neurosci Lab,Physiopathol Dept, Santiago, Chile

[8] Univ Desarrollo, Neurol & Psychiat Dept, Clin Alemana, Santiago, Chile

来源：

NATURE REVIEWS NEUROLOGY | 2024年 / 20卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/s41582-024-00998-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Current dementia research has developed complex models of environmental-genetic interactions to better address multimodal disease phenotypes. New evidence highlights a stronger effect of social determinants of health than ancestry effects specific to Latin America and the Caribbean, which opens new agendas to address the diversity of these interactions in ageing and dementia. A new study on dementia prevalence in Latin America has found a stronger effect of social determinants of health than ancestry effects specific to this region, highlighting the need for interventions involving lifestyle changes, healthcare access and education.

引用

页码：571 / 572

页数：2

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