Generation of an induced pluripotent stem cell (iPSC) line (EXSURGi001-A) from a patient homozygous for the p.Ala165Thr mutation in the MTARC1 gene

被引：0
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作者：
Tang, Peter [1 ,2 ]
Keshi, Eriselda [1 ,2 ]
Wilken, Silvana [1 ,2 ]
Wutsdorff, Louise [1 ,2 ]
Mougnekabol, Julienne [1 ,2 ]
Pratschke, Johann [1 ,2 ]
Sauer, Igor M. [1 ,2 ]
Haep, Nils [1 ,2 ,3 ]
机构：
[1] Charite Univ Med Berlin, Dept Surg, Campus Virchow Klinikum, Expt Surg, Augustenburger Pl 1, D-13353 Berlin, Germany
[2] Humboldt Univ, Freie Univ Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany
[3] Berlin Inst Hlth Charite BIH, Clinician Scientist Program, Anna Louisa Karsch Str 2, D-10178 Berlin, Germany
来源：
STEM CELL RESEARCH | 2024年 / 80卷
关键词：
D O I：
10.1016/j.scr.2024.103516
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Metabolic dysfunction-associated fatty liver disease (MAFLD), the leading cause of end-stage liver disease in developed countries, is expected to increase over the next decade. Characterized by hepatic steatosis, MAFLD is commonly studied in animal models. Here, we generated a human induced pluripotent stem cell (iPSC) line from a patient homozygous of the protective MTARC1 gene variant rs2642438:A. This line displays a normal karyotype and typical pluripotent stem cell morphology and can differentiate into all three germ layers in vitro. .
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页数：4
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