Proteomics in Cardiovascular disease

被引:0
|
作者
Gong, Miao [1 ,2 ]
Zhang, Yu [1 ,2 ]
Chen, Ning [1 ,2 ]
Ma, Lin-Lin [1 ,2 ]
Feng, Xu-Man [1 ,2 ]
Yan, Yu-Xiang [1 ,2 ,3 ]
机构
[1] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China
[2] Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China
[3] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China
基金
北京市自然科学基金; 中国国家自然科学基金;
关键词
Proteomics; Cardiovascular disease; Diagnosis; Biomarker; ACUTE CORONARY SYNDROME; PULMONARY ARTERIAL-HYPERTENSION; SERUM-PROTEIN SIGNATURE; RISK-FACTORS; BIOMARKERS; DIAGNOSIS; HEART; IDENTIFICATION; DISCOVERY;
D O I
10.1016/j.cca.2024.117877
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
This study focuses on recent advances in proteomics and provides an up-to-date use of this technology in identifying cardiovascular disease (CVD) biomarkers. A total of eight electronic databases (PubMed, EMBASE, Web of Science, Cochrane Library, Wanfang, Vip, Sinomed, and CNKI) were searched and five were used for integrative analysis of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic ratio (DOR) and 1 secondary indicator area under the curve (AUC). This systematic review and integrative analysis summarized potential biomarkers previously identified by proteomics. The integrative analysis suggested that proteomics technology had high clinical value in CVD diagnosis. The findings provided new possible directions for the prevention or diagnosis of CVD.
引用
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页数:8
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